Kevin Anderson's bid for a Grand Slam came to an end Wednesday night.
Wawrinka, who has yet to drop a set during the tournament, defeated the South African in an hour and 47 minutes. Anderson won their previous four meetings dating back to March 2014 but with the victory, Wawrinka has leveled their head-to-head series at 4 wins apiece.
Wawrinka will play his fellow countrymen No. 2 Roger Federer in the semifinals. Federer defeated No. 12 Richard Gasquet, of France, in straight sets 6-3, 6-3, 6-1.
Anderson upset No. 3 seed Andy Murray in the fourth round Monday to advance to his first career quarterfinal. He reached the fourth round in the Australian Open, French Open and Wimbledon this season.